This original book provides readers with an overview of the latest developments in personalized medicine clinical trials in oncology. The topics covered range from the rationale behind this new generation of clinical trials and the latest statistical models for high-throughput molecular techniques, bioinformatics, high-throughput screening molecular techniques and the challenges entailed by implementing them in daily practice. It also covers the key role of pathology in the validation of molecular results and the complex assessment of predictive biomarkers. The different topics covered are supplemented by unique concrete examples based on the SHIVA trial. The authors are all members of the French Curie Institute, one of the worldas foremost cancer research institutions.In general, these genes are involved in genome stability, via DNA repair, and help prevent accumulation of mutations in gatekeeper genes or oncogenes. Caretaker mechanisms include DNA base excision repair, nucleotide excision repair, anbsp;...
|Title||:||Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine|
|Author||:||Christophe Le Tourneau, Maud Kamal|
|Publisher||:||Springer - 2015-08-27|