This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinsonas disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.These hnRNPs share a highly homologous poly(ADP-ribose) binding motif in the RNA recognition domain. ... In vitro studies have demonstrated that poly(ADP- ribose) binding at the target sites is able to block (or reverse) p53 association bothanbsp;...
|Publisher||:||Springer Science & Business Media - 2008-01-11|