Primer on Multiple Sclerosis

Primer on Multiple Sclerosis

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Primer on Multiple Sclerosis was developed to provide a comprehensive overview of the clinical and basic science aspects of MS. It is designed to be of practical use to clinical neurologists, and addresses all of the major issues that may occur in the management of persons with MS. The reader is provided with the latest information on the science of MS, including immunology, genetics, epidemiology and pathology, as well as a summary of the newest directions in basic science research. Guidelines for diagnosis and appropriate use of diagnostic modalities are presented. All clinical aspects of MS are discussed, including extensive information on aspects that may be more challenging for the neurologist to manage, such as sleep disorders and pain. Disease modifying therapies, including those that are FDA approved, as well as off label and experimental therapies are discussed. Finally, there are chapters on employment and legal issues, as well as an overview of clinical trials and clinical trial outcome measures, which are helpful in reviewing the scientific literature in these areas.As previously indicated, remyelination is a common occurrence in MS, but it eventually fails to keep up with cumulative damage. ... cell functions, such as myelin formation by mature oligodendrocytes (McMillan and Kahn, 2005 ; Marson et al., 2008). ... In addition, oligodendrocytes or oligodendrocyte precursor cells may not be able to effect myelin repair in the ... from the brain of one MS patient, providing proof of concept that Th17 cells infiltrate the CNS in MS (Montes et al., 2009).

Title:Primer on Multiple Sclerosis
Author:Barbara S. Giesser, MD
Publisher:Oxford University Press - 2010-11-18


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