There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.Exp Neurol 198:313a325 Liao W, Xie J, Han ZC et al (2009) Therapeutic effect of human umbilical cord multipotent mesenchymal ... blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: a pilot investigation . ... Ann Neurol 54:403a414 Onda T, Honmou O, Harada K et al (2008) Therapeutic benefits by human mesenchymal stem cells ... Keating A (2007) Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury.
|Title||:||Progenitor Cell Therapy for Neurological Injury|
|Author||:||Charles S Cox|
|Publisher||:||Springer Science & Business Media - 2010-11-25|