Beschreibung: This thesis evaluates molecular mechanisms involved in acute respiratory distress syndrome and ventilator-induced lung injury. Open-lung ventilation strategies are known to be lung protective. Different molecular biological and immunohistochemical research methods provided discoveries in the lung protective mechanisms induced by open-lung ventilation strategies. The thesis illustrates these scientific findings imbedded in detailed description of the used research methods and basic as well as up-to-date knowledge of acute respiratory distress syndrome, ventilator-induced lung injury, and cell death mechanisms. Coloured figures facilitate the understanding of the findings.Buckley S, Driscoll B, Barsky L, Weinberg K, Anderson K, Warburton D. ERK activation protects against DNA damage and apoptosis in hyperoxic rat ... Nature, 410(6824), 37-40 (2001) Chapman KE, Sinclair SE, Zhuang D, Hassid A, Desai LP, Waters CM. ... Epithelial repair mechanisms in the lung. ... Cuschieri J, Maier RV.
|Title||:||Protective signalling mechanisms in the lung induced by open-lung ventilation strategies|
|Publisher||:||Lehmanns Media - 2013|