This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.34. model for the polymorphic residue or its structural neighborhood summarizes the observed mutability of the local structure ... interface with other protein subunits, or residues that are conserved in phylogeny will all be likely to affect biological function. ... Of course, the existence of a structural model does not obviate the insight from the purely sequence-based ... The polymorphism introduces a proline residue into a region of helix helical secondary structure Ligand The polymorphicanbsp;...
|Publisher||:||CRC Press - 2003-03-18|