Drug research and discovery are of critical importance in human health care. Computational approaches for drug lead discovery and optimization have proven successful in many recent research programs. These methods have grown in their effectiveness not only because of improved understanding of the basic science, but also because of advances in algorithms, representations, and mathematical procedures for studying such processes. This volume surveys some of those advances. A broad landscape of high-profile topics in computer- assisted molecular design (CAMD) directed to drug design are included.... are based on long-established methods for the processing of two-dimensional (2D) chemical structure diagrams (Morgan, ... and Department of Information Studies, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom.
|Title||:||Rational Drug Design|
|Author||:||Donald G. Truhlar|
|Publisher||:||Springer Science & Business Media - 1999-03-12|