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Rhabdoviruses are a diverse family of single stranded, negative sense RNA viruses that can successfully utilize a myriad of ecological niches, ranging from plants and insects to fish and mammals. This virus family includes pathogens, such as rabies virus, vesicular stomatitis virus, and potato yellow dwarf virus that are of tremendous public health, veterinary, and agricultural significance. Due to the relative simplicity of their genomes and morphology, in recent years rhabdoviruses have become powerful model systems for studying molecular virology. Written by a select group of world-renowned virologists, this book reviews all of the most recent advances in rhabdovirology, providing a timely overview of the field. Most contributions are written from a molecular and genomic perspective and contain expert insights upon which to base future research efforts. The topics covered include: morphology * genome organization * transcription * virus replication * taxonomy * characterization * virus evolution * vesiculovirus * lyssavirus * ephemeroviruses * fish novirhabdoviruses * the sigma viruses of Drosophila * virus-host protein interaction of plant-adapted rhabdoviruses * cereal-infecting rhabdoviruses * rabies prevention and control, including lyssavirus vaccine development. The book is a qmust readq for all virologists working on these and related negative sense RNA viruses. It is recommended for all biology, veterinary, and medical libraries.The main challenges in rabies control and prevention are not only in vaccine development but also in vaccine ... Introduction Efforts to improve potency, safety, delivery and cost-effectiveness are driving current rabies vaccine development. From a ... Many current public health threats arise from zoonotic infectious diseases.

Author:Ralf Georg Dietzgen, Ivan V. Kuzmin
Publisher:Horizon Scientific Press - 2012


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