These results begin to describe a pathway that does not seem to fit into either extrinsic or intrinsic mediated apoptosis, rather a model in which external signals initiate an intrinsic like apoptosis. Because current strategies aim to regulate important mediators of apoptosis and/or cell survival, revealing novel mechanisms could potentially serve to offer new approaches to therapeutic design.and IRF-1. How p53 plays a role in this model of cell death is a crucial part of the picture that needs to be determined by future experiments. 5.2 Siva-1 is an integral mediator of the TNFa/IFNy induced pathway The model of TNFa/IFNyanbsp;...
|Title||:||Siva-1 is Required for TNF-alpha/IFN-gamma Induced Apoptosis Via Reactive Oxygen Species Regulation|
|Publisher||:||ProQuest - 2008|