Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. ac Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives ac Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches ac Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques ac Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory settingThe latest estimate of the size of lipinskia#39;s chemical space is around 1033 compounds . ... Chemical structures are carefully chosen to answer structural hypotheses and employ essential elements (e.g., scaffolds) that were shown to conveyanbsp;...
|Title||:||Small Molecule Medicinal Chemistry|
|Author||:||Werngard Czechtizky, Peter Hamley|
|Publisher||:||John Wiley & Sons - 2015-09-25|