This comprehensive ebook covers all the aspects of ADME/PK modeling including solubility, absorption, formulation, metabolic stability, drug-drug interaction potential and a special delivery tool of drug candidates. the book provides an integrated view of fundamental ADME issues and challenges in early drug development from the aspect of practicing drug researchers. It also provides valuable help for the medicinal chemist in the process of multiple optimization.Decoding the entry of two novel cell-penetrating peptides in HeLa cells: lipid raft- mediated endocytosis and endosomal escape. ... A putative mechanism of signal transmission. ... Res Commun 2002; 299: 85a90. ... Biochemistry 2002; 41(29): 9208-14. ... 17: 1395-1403           208 Solubility, Delivery and ADME Problems of Drugs and Drug Candidates Duda and Letoha.
|Title||:||Solubility, Delivery and ADME Problems of Drugs and Drug-Candidates|
|Author||:||Karoly Tihanyi, Monika Vastag|
|Publisher||:||Bentham Science Publishers - 2011-01-01|