Chapter Two. Functional group scope in the methylene-free, tandem enyne metathesis. An optimized procedure for methylene-free metathesis has been identified. These procedures allow the successful transformation of a diverse group of functional group rich terminal and internal alkynes to 1, 3-cyclohexadienes. The Grubbs second-generation catalyst was found to mediate this reaction in increased efficiency over the faster propagating phosphine-free catalysts.Despite this minor problem, highly coordinating alkynes with silyl ether 57d and benzyl ethers 33d were isolated in 72% and 70% ... Compounds 60e and 61e reacted with ease under the improved conditions (entries 7 and 8) to 103. R Xanbsp;...
|Title||:||Tandem Cyclopropanation/ring Closing Metathesis, Enyne Metathesis: Developments and Application Towards Natural Product Synthesis|
|Author||:||Brian Patrick Peppers|
|Publisher||:||ProQuest - 2006|