This two-volume set provides essential information on the general principles of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modification and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharmacologists, biochemists, and environmental toxicologists.... Trimethadione 3.19 Nicotine 320 Lidocaine 321 Hormones Cortisol 322 Miscellaneous Clofibric acid 323 Fluoride 324 Promethazine 325 Theophylline 326 Cotinine ... EXCRETION INTO THE EXPIRED AIR Analysis of drugs in Volume I 75.
|Title||:||Target Organ Toxicity, Volumes I and II|
|Publisher||:||CRC Press - 1999-01-01|