Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.I Pros and cons One advantage with 3D-QSAR studies is that the same protocol, i.e. steps 1-8 mentioned in Section 5.6.1, can be ... One interesting aspect of the contour maps of the derived 3D-QSAR models is their relationship to important drug-receptor interactions. ... of compounds to be synthesized and tested at a minimum. ... There are several different types of protocols available but most often are factorial design schemes used due, in part, to the ease of evaluating these set-ups.
|Title||:||Textbook of Drug Design and Discovery, Third Edition|
|Author||:||Tommy Liljefors, Povl Krogsgaard-Larsen, Ulf Madsen|
|Publisher||:||CRC Press - 2002-07-25|