This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandinsaNSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).It can be argued that each assay system has its own merits and utility. ... Here there is no escape from the need to obtain direct measurements of drug effects in these sites, but unfortunately this ... SAFER NSAIDs THROUGH COX-2 SELECTIVITY Various strategies have been employed to overcome the major problem of the severe gastrointestinal (GI) adverse effects (bleeding and ulceration) that occurs with the traditional NSAIDs (Whitehouse and Rainsford 1982; Rainsford 1997, anbsp;...
|Publisher||:||John Wiley & Sons - 2004-07-16|