High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.... WJ (2000b) Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. ... J Biol Chem 272:430a434 Potterton L, McNicholas S, Krissinel E, Gruber J, Cowtan K, Emsley P, Murshudov GN, anbsp;...
|Title||:||The Eukaryotic Replisome: a Guide to Protein Structure and Function|
|Publisher||:||Springer Science & Business Media - 2012-08-23|