The final chapter is the analysis of the behavior of the human engineered Top7 protein using numerical and experimental methods. The numerical results were basis for the rationally introduced mutations which showed to be able to significantly increase the mechanical resistance of that protein.The main features were defined through the rough two dimensional plot (Figure 5.1). ... (Taken from SCIENCE, 21 NOVEMBER 2003 V. 302 1364-1368) Three- dimensional models which satisfy steric ... from the protein with solved structures consistent with the diagram using the Rosetta43 de novo structure prediction method. ... Specific search procedures included linear and Monte Carlo searches andanbsp;...
|Title||:||The Improvement of the Nonequilibrium Free Energy Reconstruction Using Stochastic Pulling Protocol|
|Publisher||:||ProQuest - 2007|