The Mouse in Biomedical Research

The Mouse in Biomedical Research

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Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mousea€™s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.1999). In 3-month-old outbred CD-1 mice, inbred C57BL/6J, and 129Sv mice the females had a larger bile acid pool, more efficient ... Most cholesterol in the mouse is produced outside the liver, but the liver is essential to maintain stable blood levels as it excretes intact cholesterol or converts it into bile acid. ... Mice also produce ~160 mg/kg/day of cholesterol, whereas humans produce ~10 mg/ kg/day.

Title:The Mouse in Biomedical Research
Publisher:Academic Press - 2006-12-15


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