Aging occurs at the level of individual cells, a complex interplay between intrinsic qprogrammingq and exogenous qwear and tearq, with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, qThe Role of DNA Damage and Repair in Cell Agingq provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled qAdvances in Cell Aging and Gerontology, q this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.The Effect of Aging on the Repair of Specific Genes by the NER Pathway The methods used in the studies described ... rat hepatocytes show differential repair of UV-induced DNA damage that is comparable to what has been reported foranbsp;...
|Title||:||The Role of DNA Damage and Repair in Cell Aging|
|Author||:||Barbara A. Gilchrest, Vilhelm A. Bohr|
|Publisher||:||Elsevier - 2001|