Atherosclerosis is the principal underlying cause of cardiovascular and cerebrovascular disease in people of the Western world. Cigarette smoking has been implicated in both the initiation and exacerbation of the atherosclerotic process. Data to support this implication derives primarily from epidemiologic studies where the relationship between the incidence of atherosclerosis in people who smoke cigarettes has been shown to have a strong correlation. There are few well established explanations for this phenomenon, and basic molecular, biochemical, and cellular mechanisms associated with smoking and the development of atherosclerosis remain both undefined and virtually unexplored. Even the epidemiologic correlation between cigarette smoking and the development of atherosclerosis needs further critical studies. It is known that individuals who do not smoke cigarettes develop athero sclerosis and it is also known that in people who smoke but have normal or low blood cholesterol/lipoprotein levels, the incidence of development of atherosclerosis is no different from that which is found in a non smoking population. Answers which explain such observations must address fundamental biological mechanisms. Toward this end, the purpose of this volume is to assemble, in a single publication, information which will address the questions; what basic cellular and/or molecular mechanisms are associated with the development of atherosclerosis and how does cigarette smoking influence such mechanisms to initiate or exacerbate the atherosclerotic process? Clearly, the development of atherosclerosis is a complex, multifactorial biological event.Hemodynamic Measurements Before and After Intravenous Infusion of Nicotine ( n=6) Plasma ABP ABP epinephrine (mm Hg) Hct (pg/ml) Before ... animals unaccustomed to smoking, with cigarette smoke or infusing nicotine elevated the plasma epinephrine, arterial blood pressure and hematocrit. In these animals phentolamine blocked the increase in vivo platelet activity and acute thrombus formation.
|Title||:||Tobacco Smoking and Atherosclerosis|
|Author||:||John N. Diana|
|Publisher||:||Springer Science & Business Media - 2013-03-13|