Translational and Experimental Clinical Research

Translational and Experimental Clinical Research

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This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients, pharmacokinetics and pharmacodynamics, and gene therapy and pharmacogenomic studies. A major section describes modern techniques of translational clinical research, including gene expression, identifying mutations and polymorphisms, cloning, transcriptional profiling, proteomics, cell and tissue imaging, tissue banking, evaluating substrate metabolism, and in vivo imaging.Research institutions receiving federal funds are required to adopt a formal policy (and procedures) regarding misconduct ... Such expansions include policies related to authorship, academic misconduct, or questionable research practices. ... Both the NIH and the NSF have published their guidelines related to data sharing.

Title:Translational and Experimental Clinical Research
Author:Daniel P. Schuster, William J. Powers (MD.)
Publisher:Lippincott Williams & Wilkins - 2005


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